Abstract: Vacuum Assisted Flap Delay, a Novel Strategy to Increase the Flap Survival: An Experimental Study in Rabbits
نویسندگان
چکیده
Suday, Sptem er 5, 2016 pre-vascularized full thickness skin flap, which recapitulates the inherent hierarchical vasculature found within the human skin and is suitable to provide whole tissue perfusion. We provide the platform for an on-demand, geometrically tunable tissue engineered skin equivalent with an anastomosable vascular network which will transform reconstructive surgical practice by eliminating the consequences of donor site morbidity and enabling rationally designed, patient specific flaps for each unique wound environment and anatomic location.
منابع مشابه
The Effect of Enoxaparin and Clopidogrel on Survival of Random Skin Flap in Rat Animal Model
BACKGROUND Necrosis of skin flaps is considered as an important complication in reconstructive surgery. We conducted an experimental study to investigate the efficacy of low-molecular weight heparin, clopidogrel and their combination to improve the flap survival. METHODS Forty male, adult Sprague-Dawlay rats were divided randomly into 4 groups. Standard rectangular, distally based dorsal ran...
متن کاملاثر آزلائیک اسید 5% و مینوکسیدیل 5% در کاهش ناحیه نکروتیک فلاپهای پوستی در موش صحرای
Backgound and Aim: One important limitation of random pattern skin flap in plastic surgery is the necrosis of distant parts of the flap resulting from ischemia. This effect cause unwanted increase in the costs and hospitalization. Previously, large number of factors has been evaluated to decrease the flap necrosis. In present study we used two drugs. Main reason was their mechanism of action th...
متن کاملاثر محافظتی عصاره خوراکی گیاه شیرین برگ (Stevia rebaudiana ) بر بقای فلپ پوستی در موش صحرایی نر
Background and purpose: Due to the properties of Stevia, it seems that this plant can be effective in reducing oxidative damage consequent to ischemia-reperfusion, and increase the survival of skin flap. This research aimed at investigating the effects of oral extract of stevia on apoptosis and skin flap necrosis in rats. Materials and methods: In this experimental study, Sprague Dawley rats w...
متن کاملImmediate application of vacuum assisted closure dressing over free muscle flaps in the lower extremity does not compromise flap survival and results in decreased flap thickness
BACKGROUND Free muscle flaps are a mainstay for reconstruction of distal third leg wounds and for large lower extremity wounds with exposed bone. However a major problem is the significant postoperative flap swelling, which may take months to resolve. We studied the efficacy and safety of immediate application of a vacuum assisted closure (VAC) dressing after a free muscle flap to the lower ext...
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IMPORTANCE Reconstruction of oncologic or traumatic head and neck defects often requires complex planning of locoregional, pedicled, or interpolated flaps. In cases with a higher risk of flap failure, vascular delay with staged reconstruction can help improve tissue perfusion and increase chances of flap survival. An objective tool is needed to help guide reconstructive surgeons with the intrao...
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